My configuration. Minimalist, but helps save a few thousand keystrokes a day. I use macOS, so I can only guarantee they'll work on a Mac, but I use some of these dotfiles on various linux servers, and they seem to be pretty flexible.

macOS settings

Run .osx to apply macOS defaults:

./.osx

Use --no-restart while iterating:

./.osx --no-restart

The script configures:

Bottom-right trackpad corner as secondary click.
Screenshot output to ~/Downloads.
Screenshot keyboard shortcuts disabled.
Spotlight and Show Apps keyboard shortcuts disabled.
Dock recent apps disabled.
Dock hot corners, Finder defaults, Safari developer settings, and other UI preferences.

Some settings are cached by macOS services. If System Settings still shows stale shortcut checkbox state after running the script, log out and back in.